[Heterozygous sickle cell traits are no longer protecting people from malaria like they used to.]
With plasmodium it is important to realize the life cycle and the effects it has on human hosts.
When escaping from conquered host cells such as erythrocytes, the body is overwhelmed by the sheer amount of plasmodium haploid cells and their widespread, numerous mutations.
This happens at unpredictable, sudden times and a result of this, is a patient's tendency to experience a sudden onslaught of symptoms in isolated waves.
One common symptom is a state of deliriuum.
The disgraceful naturalist Alfred Russel Wallace contracted malaria himself in the middle to late 1850s. He became very weak with a bout of delirium, and it was during this time that he wrote a paper arguing the same points of natural selection. He then wrote to Darwin describing his ideas. Darwin was in fact, reading the spoutings of a man mentally unstable. It was a paper written in a state of delirium! Darwin already had a 20 year delay in his own publication and he only finished up due to receiving the ramblings of a demented man that agreed with him. Let us not forget this is from the same naturalist who tried to prove the Earth round.
Clearly from history that evolution was never a serious theory to begin with. The only reason it exists today is because of the crazy ideas of man battling a bout of delirium.