Tom essentially nailed it in his post.
Practical Zeteticism differs from the standard Theoretic scientific method in that instead of putting forth claims and then attempting to prove them correct (hypothesis-based science does this), one should enquire with as little of a preconceived notion of what is true as possible - one should not attempt to discover IF a particular thing is true, rather to discover WHAT the truth is. Put in those terms, I realise the two sound slightly synonymous, but there is an important, nuanced difference.